Volume : 10, Issue : 07, July – 2023

Title:

12.FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ACECLOFENAC

Authors :

Dunaboina Anusha*, Mr. D. Appalaraju, Mrs. M. Vineela

Abstract :

The main aim of present work was to formulate and evaluate sustain release matrix tablets of Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID). Sustain release formulation are those which delivers the drug locally or systemically at a predetermined rate for a fixed period of time. The matrix tablet was prepared by direct compression method using by various concentration of Sodium Alginate and Eudragit RLPO various release retardant polymer. The powder mixtures were subjected to various pre-compression parameters such as angle of repose, bulk density, tapped density and Carr’s index shows satisfactory result and the compressed tablets are evaluated for post-compression parameters such as weight variation, thickness, hardness, friability, drug content, in-vitro dissolution studies. In-vitro dissolution studies were carried out for 12 hours using 0.1 N HCL for first 2 hours and pH 6.8 phosphate buffer for 12 hours and the result showed that formulations F5 showed good dissolution profile to control the drug release respectively. Formulation containing lower concentration of Eudragit RLPO polymer sustained the drug release for the period of 12 hours. The kinetics studies the optimized formulation followed Zero order release kinetics.
Key words: Aceclofenac, Sodium Alginate, Eudragit RLPO, Direct compression and Sustained release matrix tablets

Cite This Article:

Please cite this article in press Dunaboina Anusha et al, Formulation And In Vitro Evaluation Of Sustained Release Matrix Tablets Of Aceclofenac., Indo Am. J. P. Sci, 2023; 10 (07).

Number of Downloads : 10

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