Volume : 10, Issue : 07, July – 2023

Title:

36.HEPATIC PROTECTIVE ACTIVITY OSBECKIA CHINENSIS

Authors :

Md. Khaja Moinuddin, Musarrath Mubeen*, Koteswari Poluri

Osbeckia chinensis leaves (Family Melastomataceae) commonly known as Melastoma a vigorously growing in India. In the present study a pharmacognostic evaluation of the leaves was undertaken. In addition to the evaluation of physicochemical characteristics; preliminary phytochemical parameters and pharmacological activities of Ethanolic extracts has been carried out. The aim of the present study was carried out with the objective of phytochemical screening and to evaluate the hepatoprotective activity of Ethanolic extract of Osbeckia chinensis.
Liver is the largest organ in the body which serves as a gland also. It plays an important role in the maintenance of internal environment through its multiple and diverse functions. Any damage to the liver or impairment of its functions leads to injurious effects. Liver diseases (like jaundice) are the common ailments affecting mankind, though no remedy is available in allopathic at present. In the recent past years many medicinal plants are screened for their hepatoprotective activity and quite a few of they are already successful in entering the market, Hence the present study is planned to find out the hepatoprotective activity of Osbeckia chinensis drug induced hepatotoxicity methods. The rats were divided into five groups with three rats in each for three models. Group I (Control) served as normal and received the vehicle alone (Sterile distilled water, 10 ml/kg, p.o.) for 21 days. Group II (control and 40% ethanol) animals on the 21 day. Group III Received 40% ethanol v/v (2.0ml/l00g body wt, p.o.) for 21 days and standard drug silymarin (25 mg/kg. p.o.) for 21 days once daily and IV were treated with 40% ethanol and Ethanolic extract of Osbeckia chinensis (400 mg/kg) 21 days once daily. Group V was treated with Received 40% ethanol and Ethanolic extract of Osbeckia chinensis (200 mg/kg) 21 days once daily the animals were sacrificed 48 h after the last injection of hepatotoxic drugs under mild ether anesthesia. The blood was collected and allowed to stand for 30 min at 37°C and then centrifuged to separate the serum to estimate various biochemical parameters.
In hepatoprotective studies, the toxicity elevated levels of serum marker enzymes Total Bilirubin ALT, AST, ALP, SGOP and SGPT levels. Ethanol induced hepatotoxicity was significantly prevented by pretreatment ethanolic extract of leaves. Decrease in wet liver weight, reduction in elevated biochemical parameter levels like serum SGPT, SGOT, and total bilirubin, after treatment with Ethanolic extract of Osbeckia chinensis leaves confirmed the hepatoprotective effect of extract under study. In liver injury models in rats restoration of hepatic cells with minor fatty changes and absence of necrosis after treatment with extract was observed, indicating satisfactory hepatoprotection.
The data obtained from animal experiments are expressed as mean ± SEM (standard error of mean). For statistical analysis data were subjected to analysis of variance (ANOVA) followed by Student’s t-test. Values are considered statistically significant at p < 0.01 for ANOVA and P < 0.05 for t-test.
Keywords: Osbeckia chinensis, Hepatoprotective activity, Alkaline Phosphate, Aspartate amino trasferase, Alanine amino transferase.

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