Volume : 10, Issue : 11, November – 2023

Title:

OPTIMIZING MUCOADHESIVE TABLETS OF LERCANIDIPINE: FORMULATION DEVELOPMENT AND EVALUATION

Authors :

Vikash Singh*, Mrs. Reena Shende, Dr. Satkar Prasad

Abstract :

Arterial hypertension, the prevailing cardiovascular ailment associated with escalating obesity rates and sedentary lifestyles, often necessitates changes in therapy due to the challenges posed by traditional antihypertensive medications. This study endeavors to address these issues through the development and evaluation of mucoadhesive buccal tablets of Lercanidipine. Formulation and evaluation procedures were conducted according to standard protocols, resulting in six formulations with varying ingredient concentrations. The results indicated that the bulk density of the formulations ranged from 0.374 to 0.385, while tapped density varied from 0.473 to 0.492. The compressibility index fell within the range of 21.75 to 23.00, and the Hausner ratio ranged from 1.278 to 1.299. Formulation F3 exhibited the highest drug content at 99.45±0.20%. The thickness and hardness for F3 were 3.11±0.04 mm and 5.4±0.4 kg/cm^2, respectively, while weight variation and friability were measured at 246±7 mg and 0.658±0.013%. The maximum swelling in the F3 formulation at 12 hours reached 103.25%, indicating its potential for effective drug release. The % Cumulative Drug Release for F3 at 12 hours was observed to be 99.45%. Regression coefficient values were compared, revealing that the ‘r2’ values of the First Order kinetics were maximized, reaching 0.978. This suggests that drug release from the formulations follows First Order kinetics. In conclusion, the F3 formulation demonstrated ideal parameters, ensuring rapid action and offering a viable alternative to traditional tablets for the management of arterial hypertension.
Keywords: Hypertension, Buccal drug delivery, Muucoadhesive tablets, Lercanidipine

Cite This Article:

Please cite this article in Vikash Singh et al, Optimizing Mucoadhesive Tablets Of Lercanidipine: Formulation Development And Evaluation, Indo Am. J. P. Sci, 2023; 10 (11).

Number of Downloads : 10

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