Volume : 10, Issue : 11, November – 2023
Title:
FORMULATION AND EVALUATION OF LINAGLIPTIN MICROSPHERES BY USING DIFFERENT POLYMERS
Authors :
Mohd. Rizwan Hussain*, Dr. M. Sunitha Reddy
Abstract :
In the present work, Microspheres of Linagliptin using PLGA, Ethyl cellulose and HPMC K4M as polymers were formulated to deliver Linagliptin via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Linagliptin microspheres. In this work an effort was made to formulate microsphere of Linagliptin by using different polymers. Prepared formulations are evaluated for bulk density, tapped density, precent mucoadhesion, Percent compressibility, hausners ration, percentage yield, size and interaction study by Differential scanning calorimeter and in vitro drug release. Formulation which passed all the evaluation parameters was considered as best formulation of Linagliptin. The present study conclusively that Linagliptin microsphere could be prepared successfully and formulation F5 was shows satisfactory result.
Keywords: Linagliptin, PLGA, Ethyl cellulose and HPMC K4M and Microspheres.
Cite This Article:
Please cite this article in Mohd. Rizwan Hussain et al, Formulation And Evaluation Of Linagliptin Microspheres By Using Different Polymers, Indo Am. J. P. Sci, 2023; 10 (11).
Number of Downloads : 10
References:
1. Kadam N. R. and Suvarna V. Microspheres: A Brief Review. Asian Journal of Biomedical and Pharmaceutical Sciences, 2015.
2. Patel N. R., Patel D. A., Bharadia P.D., Pandya V., Modi D.,Microsphere as a novel drug delivery, Int. j. pharm. life sci. 2011;2(8):992-7.
3. Singh C., Purohit S., Singh M., Pandey B.L., Design and evaluation of microspheres: A Review, jddr. 2013;2(2):18-27.
4. Prasanth v.v., Moy A. C., Mathew S. T., Mathapan R., MicrospheresAn overview, Int. J. Res. Pharm. Biomed. Sci., 2011;2:3328.
5. Sree Giri Prasad B., Gupta V. R. M., Devanna N., Jayasurya K., Microspheres as drug delivery system – A review, JGTPS. 2014;5(3): 1961 -72.
6. Mohan M., Sujitha H., Dr. Rao V. U. M., Ashok M., Arun kumar B., A brief review on mucoadhesive microspheres, IJRRPAS.2014;4(1):975-86.
7. Kumar A., Jha S., Rawal R., Chauhan P.S., Maurya S. D., Mucoadhesive microspheres for novel drug delivery system: A Review, Am. J. Pharm Tech Res.2013;3(4):197-213.
8. Thummar A.V., Kyada C.R., Kalyanvat R., Shreevastva B., A review on mucoadhesive microspheres as a novel drug delivery system, International Journal for Pharmaceutical Research Scholars.2013;2(2):188-200.
9. Mukherjee S., Bandyopadhyay P., Magnetic microspheres: A latest approach in novel drug delivery system, JPSI. 2012;1(5):21-25.
10. Batra D., Kakar S., Singh R., Nautiyal U.,Magnetic microspheres as a targeted drug delivery system:An overview, Jddr. 2012;1(3):1-17.
11. Dutta P., Sruti J., Patra Ch. N., Rao M. E. B.,Floating microspheres: Recent trends in the development of gastrorententive floating drug delivery system, Int. J. Pharm. Sci. Nanotech. 2011;4(1):1296-1306.
12. Mukund J. Y., Kantilal B. R., Sudhakar R. N., Floating microspheres: A review, Braz. J. Pharm. Sci. 2012;48(1):17-30.
13. Kawatra M., Jain U., Ramana J., Recent advances in floating microspheres as gastro-retentive drug delivery system: A review, IJRAPR. 2012;2(3):5-23.
14. Ramteke K.H., Jadhav V.B., Dhole S.N., Microspheres: As carrieres used for novel drug delivery system, IOSRPHR. 2012;2(4):44-48.
15. Dupinder K., Seema S., Gurpreet S., Rana A.C., Biodegradable microspheres: A review, IRJP.2012; 3(12):23-27.