Volume : 10, Issue : 11, November – 2023
Title:
THE EMERGING TRENDS OF NANOPARTICLES IN THE TREATMENT OF DIABETES
Authors :
Devesh S. Haramkar*, Mr. Jugalkishor Vyas, Shreyash Padmawar
Abstract :
The review was carried out to discuss in detail about the polymeric nanoparticles for diabetic treatment. The diabetes is the chronic metabolic disorder characterized by the deficiency of insulin production. The various treatments are available for the diabetes and the nanoparticles are having the several advantages. The various types of nanoparticles are available for the anti-diabetic drugs; the polymeric nanoparticles are the one of the most commonly used nanoparticles. The polymeric nanoparticles are commonly 10-1000nm in size. The polymeric nanoparticles are formulated by drug with the polymers. The main advantages of the polymeric nanoparticles are the simplest preparation method, targeted delivery, the minimizing of the dose and high therapeutic efficiency. In this review was mainly can be focused on advantages, disadvantages of polymeric nanoparticles, various polymers, various formulation techniques, diabetes disease profile, insulin production, various anti-diabetic drugs and the polymeric nanoparticle formulation of anti-diabetic drugs.This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally.
Keywords: Diabetes, Nanoparticle, Liposome, Insulin, Polymer.
Cite This Article:
Please cite this article in Devesh S. Haramkar et al, The Emerging Trends Of Nanoparticles In The Treatment Of Diabetes, Indo Am. J. P. Sci, 2023; 10 (11).
Number of Downloads : 10
References:
1. Rai VK, Mishra N, Agrawal AK, Jain S, Yadav NP. Novel drug delivery system: an immense hope for diabetics. Drug delivery. 2016; 23(7):2371- 90.
2. He Y, Al-Mureish A, Wu N. Nanotechnology in the treatment of diabetic complications: a comprehensive narrative review. Journal of Diabetes Research. 2021 3; 2021.
3. Shelke A, Zilate S. Recent Trends in the Therapeutic Approach of Type 2 Diabetes Mellitus. Journal of Pharmaceutical Research International. 2021; 33(60B):3662-3668.
4. Samadder A, Khuda-Bukhsh AR. Nanotechnological approaches in diabetes treatment: A new horizon. World Journal of Translational Medicine. 2014; 3(2):84-95.
5. Zolkepli H, Widodo RT, Mahmood S, Salim N, Awang K, Ahmad N, Othman R. A Review on the Delivery of Plant-Based Antidiabetic Agents Using Nanocarriers: Current Status and Their Role in Combatting Hyperglycaemia. Polymers. 2022; 14(15):2991.
6. Najigivi ID, Mirmotallebi S, Najigivi A. Contribution of Nanotechnology and Nanomaterials to the Treatment of Diabetic Patients by Aid of Novel Inventions. Journal of American Science. 2020; 16(5)
7. A.R. Bender, et al., Efficiency of nanoparticles as a carrier system for antiviral agents in human immunodeficiency virus-infected human monocytes/macrophages in vitro, Antimicrob. Agents Chemother. 40 (6) (1996) 1467–1471.
8.S. Bonduelle, et al., Association of cyclosporin to isohexylcyanoacrylate nanospheres and subsequent release in human plasma in vitro, J. Microencapsul. 9 (2) (1992) 173–182.
9.M. Jahanshahi, Z. Babaei, Protein nanoparticle: a unique system as drug delivery vehicles, Afr. J. Biotech. 7 (2008) 4926.
10.Y. Kawashima, et al., Mucoadhesive d,l-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin, Pharm. Dev. Technol. 5 (1) (2000) 77–85.
11. Nagarajan E., Shanmugasundaram P., Ravichandiran V., Vijayalakshmi A., Senthilnathan B. and Masilamani K.(2015); Development and Evaluation of Chitosan Based Polymeric Nanoparticles of an Antiulcer Drug Lansoprazole; JAPS; Vol. 5 No. 4; 20-25.
12. Nagavarma B.V.N., Hemant K.S. Yadav, Ayaz A., Vasudha S. and Shivakumar H.G.(2012); Different techniques for preparation of polymeric nanoparticles- A review; Asian J Pharm Clin Res.; Vol. 5 No.3; 16-23.
13. Neha Yadav, Sunil Khatak and Udai Vir Singh S.A.(2013); Solid lipid nanoparticles- A review; Int J App Pharm; Vol. 5 No.2; 8-18.
14. Naik J.B. and Mokale V.J.(2012); Formulation and evaluation of Repaglimide nanoparticles as sustained release carriers; International Journal of Pharmaceutical Sciences; Vol. 1 No. 5; 259-266.
15. Mura, S., Nicolas, J., & Couvreur, P. (2013). Stimuli-responsive nanocarriers for drug delivery. Nature materials , 12 (11), 991-1003.
16. Rahimnejad, M., Rabiee, N., Ahmadi, S., Jahangiri, S., Sajadi, S. M., Akhavan, O., . . . & Hahn, S. K. (2021). Emerging phospholipid nanobiomaterials for biomedical applications to lab-on-a-chip, drug delivery, and cellular engineering. ACS Applied Bio Materials , 4 (12), 8110-8128.
17. Kluin, O. S., Van der Mei, H. C., Busscher, H. J., & Neut, D. (2013). Biodegradable vs nonbiodegradable antibiotic delivery devices in the treatment of osteomyelitis. Expert opinion on drug delivery , 10 (3), 341-351.
18. De Jong, W. H., & Borm, P. J. (2008). Drug delivery and nanoparticles:applications and hazards. International journal of nanomedicine , 3 (2), 133–149.
19. S. Gopi, A. Amalraj, S. Thomas, Effective drug delivery system of biopolymers based on nanomaterials and hydrogels e a review, Drug Design 5 (2016) 1-7.
20. Hasnain, M. S., Ahmed, S. A., Alkahtani, S., Milivojevic, M., Kandar, C. C., Dhara, A. K., & Nayak, A. K. (2020). Biopolymers for drug delivery. In Advanced biopolymeric systems for drug delivery (pp. 1-29). Springer, Cham.
21. Saba Hasan. A Review on Nanoparticles: Their Synthesis and Types. Research Journal of Recent Sciences, 2015;4:1-3.
22. VJ Mohanraj, Y Chen. Nanoparticles – A Review. Tropical Journal of Pharmaceutical Research, 2006;5(1):561-573.
23. Khan Ibrahim, Saeed Khalid, Khan Idrees. Nanoparticles: Properties, applications and toxicities. Arabian Journal of Chemistry, 2017; 12:908-931.
24. Bhatia Saurabh. Natural Polymer Drug Delivery Systems. Springer International Publishing Switzerland,2016:40.
25. Murthy Shashi K. Nanoparticles In Modern Medicine: State Of The Art And Future Challenges. International Journal of Nanomedicine, 2007; 2(2):129-141.
26.Madkour, L. H. (2019) Introduction to nanotechnology (NT) and nanomaterials (NMs). In Nanoelectronic Materials, pp. 1-47. Springer, Cham.
27.Maity, S., Mukhopadhyay, P., Kundu, P. P. and Chakraborti, A. S. (2017) Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals-an in vitro and in vivo approach. Carbohydr. Polym. 170, 124-132.
28.Mansoori, S., Davarnejad, R., Matsuura, T. and Ismail, A. F. (2020) Membranes based on non-synthetic (natural) polymers for wastewater treatment. Polym. Test. 84, 106381.
29.McClements, D. J. (2018) Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: a review. Adv. Colloid Interface Sci. 253, 1-22. 30)Mohammadi, M., Jafari, S. M., Hamishehkar, H. and Ghanbarzadeh, B. (2020) Phytosterols as the core or stabilizing agent in different nanocarriers. Trends Food Sci. Technol. 101, 73-88.
31.Mohseni, R., ArabSadeghabadi, Z., Ziamajidi, N., Abbasalipourkabir, R. and RezaeiFarimani, A. (2019) Oral administration of resveratrol-loaded solid lipid nanoparticle improves insulin resistance through targeting expression of SNARE proteins in adipose and muscle tissue in rats with type 2 diabetes. Nanoscale Res. Lett. 14, 227.
32. Binder C, Lauritzen T, Faber O, Pramming S. Insulin pharmacokinetics. Diabetes care. 1984;7(2):188-99.
33. Feng S. Nanomedicine: nanoparticles of biodegradable polymers for cancer diagnosis and treatment. Cosmos. 2008;4(02):185-201.
34. Calceti P, Salmaso S, Walker G, Bernkop-Schnürch A. Development and in vivo evaluation of an oral insulin–PEG delivery system. European Journal of Pharmaceutical Sciences. 2004;22(4):315-23.
35. Scott‐Moncrieff JC, Shao Z, Mitra AK. Enhancement of intestinal insulin absorption by bile salt–fatty acid mixed micelles in dogs. Journal of pharmaceutical sciences. 1994;83(10):1465-9.