Volume : 10, Issue : 10, October – 2023
Title:
DESIGN AND IN VITRO EVALUATION OF GLIPIZIDE ONCE DAILY TABLET USING NATURAL GUMS
Authors :
P. N. Mallikarjun*, K. E. V. Nagoji
Abstract :
The main purpose of the present work is to study Lannea coramondelica gum and Terminalia catappa gum functionality as release retardant agents in the design of once daily matrix tablets of Glipizide. Lannea coramondelica gum(LCG) and terminalia catappa gum(TCG) are purified forms of exudates obtained from the respective trees by an established method. Fourier transform infrared spectroscopy studies were performed to find out the interactions between gum and drug. Here matrix tablets of Glipizide were prepared with gums bywet granulation technique. The granules were evaluated for angle of repose, bulk density and compressibility index. The granules showed satisfactory flow properties. Tablets thus formulated were evaluated for various quality control tests like weight variation, hardness, friability etc. All Glipizide matrix tablets were found to have better uniformity of weight and drug content with low SD values. The dissolution study proved that the LCG and TCG can be used as a matrix forming material for making extended release tablets. The kinetic release data fitted into different mathematical models (Zero order, First order, Higuchi, Peppa’s. Most of the solid matrix formulations followed Higuchi or zero order kinetics.
KEYWORDS: Glipizide, Lannea coramondelica gum (LCG) and Terminalia catappa gum (TCG)), matrix tablets.
Cite This Article:
Please cite this article in P. N. Mallikarjun et al Design And In Vitro Evaluation Of Glipizide Once Daily Tablet Using Natural Gums, Indo Am. J. P. Sci, 2023; 10 (10).
Number of Downloads : 10
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