Volume : 10, Issue : 10, October – 2023
Title:
FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS
Authors :
Sirigadha Ramprasad *, Mr. Dr.D.Venkata Ramana , Mrs. J.Pravalika
Abstract :
In the present work, an attempt has been made to developed Controlled release tablets of Felodipine by selecting different types of Na CMC, HPMC K 100 and Sodium alginate as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among the entire formulations 9 formulations showed maximum % drug release i.e., 98.68 % in 12 hours. Hence it is considered as optimized formulation F5 which contains HPMC K 100 (30mg). The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Peppas release kinetics mechanism of drug release.
Keywords: Felodipine, Na CMC, HPMC K 100, Sodium alginate and Controlled release tablets.
Cite This Article:
Please cite this article in press Takur Nagamalleshwari Bai et al, Formulation And Evaluation Of Controlled Release Tablets Of Felodipine, Indo Am. J. P. Sci, 2023; 10 (10).
Number of Downloads : 10
References:
1. Modi Kushal ,Modi Monali, Mishra Durgavati, Panchal Mittal ,Sorathiya Umesh, Shelat PragnaModi Kushal, Modi Monali, Mishra Durgavati, Panchal Mittal, Sorathiya Umesh, Shelat Pragna. Oral Controlled Release Drug Delivery System: An Overview. Int. Res. J. Pharm. 2013, 4 (3).
2. H.D.Zalte , R.B.Saudagar. Review On Sustained Release Matrix Tablet. IJPBS -Volume 3-Issue 4 -OCT-DEC-2013-17-29.
3. Kumar A., Raj V., Riyaz Md., Singh S., Review on sustained release matrix formulations, International Journal of Pharmacy and Integrated Life Sciences.1(3):1-14,(2013)
4. Pundir S., Badola A.,Sharma D.,Sustained release matrix technology and recent advance in matrix drug delivery system : a review. International Journal of Drug Research andTechnology,3(1):12-20, (2013)
5. Jaimini M., Kothari A., Sustained release matrix type drug delivery system: A review. Journal of Drug Delivery & Therapeutics. 2(6):142-148,(2012)
6. Brahmankar D.M., Jaiswal S B., Biopharmaceutics and Pharmacokinetics: Pharmacokinetics, 2nd Edn, published by Vallabh Prakashan, Delhi 399-401,(2009)
7. Kumar S.K.P., Debjit B., Srivastava S., Paswan S., Dutta AS., Sustained Release Drug Delivery system potential, The Pharma innovation.1(2):48-60,(2012)
8. Dusane A.R.,Gaikwad P.D., Bankar V.H, Pawar S.P., A Review on Sustain release technology, International journal research in ayurvedic and pharmacy.2(6):1701- 1708,(2011).
9. Remington: The Science and Practice of Pharmacy,21st Edn, Vol 1, Published by: Wolter Kluwer Health (India):939-964,(2006)
10. Chugh I., Seth N., Rana A.C., Gupta S,.Oral sustain release drug delivery system: an overview, International research journal of pharmacy.3(5):57- 62,(2012)
11. Lieberman.H.A., Lachman.L., and kanig J L.,The theory and practice of industrial pharmacy, 3rd Edn, Published by: Varghese publishing house:430-456.
12. Sathish Ummadi, B. Shravani, N. G. Raghavendra Rao, M. Srikanth Reddy, B. Sanjeev Nayak. Overview on Controlled Release Dosage Form. Vol. 3, No. 4 (2013): 258-269.
13. Gilbert S, Banker ; Christopher T; Rhodes; “ Modern Pharmaceutical 3rd Edition” :576-578
14. Lachman Leon, Lieberman Herbert A. Compression coated and layer tablets. In: Pharmaceutical Dosage Forms: Tablets. Marcel Dekker, Inc., New York, 2002; vol 1; 2nd edition: 247- 84.
15. Gennaro Alfonso R. Extended Release Dosage Forms. In: Remington: The Science and Practice of Pharmacy. Lippincott Williams and Wilkins, U.S.A, 2000; vol 1; 20th edition: 660- 63.