Volume : 10, Issue : 10, October – 2023
Title:
DEVELOPMENT OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY SYSTEM FOR AN ANTI-PSYCHOTIC DRUG
Authors :
*Damineni Saritha, Uroosa Arsheena, Anupama Koneru, P. Subhash Chandra Bose
Abstract :
Purpose: The present study was intended to develop lurasidone micro emulsion for intranasal delivery in the treatment of psychosis.
Methods: Sesame oil, tween-20(surfactant) and plurol oleique(co-surfactant) were selected based on the solubility of lurasidone. Pseudo ternary phase diagram was constructed to know the surfactant: co surfactant ratio which can form microemulsion. The prepared micro emulsion was characterized for FTIR, thermodynamic stability, droplet size and zeta potential, drug content, in-vitro diffusion study, stability study and release kinetics.
Results & Conclusion: The ratio of surfactant to co surfactant 1:2 and 1:3 were selected from the pseudo ternary phase diagrams. Among all the formulations LA1 showed higher diffusion rate (99.11%) with a particle size of 3.957µm and zeta potential above 50mv. The optimised formulation was stable for a period of 3 months. Thus Lurasidone intranasal micro emulsion was developed which improved solubility and hence in-vitro diffusion of the drug.
KEY WORDS: Micro emulsion, intranasal drug delivery, pseudo ternary phase diagram, zeta potential.
Cite This Article:
Please cite this article in press Damineni Saritha et al, Development Of Microemulsion Based Intranasal Drug Delivery System For An Anti-Psychotic Drug, Indo Am. J. P. Sci, 2023; 10 (10).
Number of Downloads : 10
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