Volume : 10, Issue : 09, September – 2023
Title:
33.FORMULATION AND EVALAUTION OF EPROSARTAN MESYLATE FLOATING TABLETS
Authors :
Gudepu Chaithanya, Thadakapally Ramchander
Abstract :
Eprosartan mesylate is angiotensin-II receptor antagonist used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. Direct compression method was selected for preparation of tablets and the drug is formulated with hydroxyl propyl methyl cellulose (HPMC) K15M, hydroxyl propyl methyl cellulose E15, Xanthan gum, Guar gum, Chitosan, Carbopol 940 P, Carbopol 934P etc. Eight formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content, In-vitro buoyancy studies and In-vitro drug release and the results obtained for the performed tests were found within the range of specified limits. Based on studies of floating lag time and entire floating time, uniformity of medication content, and in vitro dissolution, the preparation comprising karaya gum (F7) was chosen as the improved formulation because it had the smallest FLT of 1 sec, the longest TFT of 580 min, and the highest percentage of drug release at the termination of 600 min. It was subsequently given a release kinetics investigation, and the maximum correlation coefficient revealed t a zero-order non-fickian diffusion-controlled system. When the optimum preparation compared to FTIR results of pure drug, it was discovered that there was no drug-excipient interaction. Following stability investigations, it was discovered that the investigated post-compression parameters had not undergone any significant modifications. From the above findings, it was determined that Eprosartan mesilate floating tablets comprising karaya gum (F7) prolong the retaining of dosage form in stomach area for extended time and reduce drug variation in plasma concentration by regular treating of conventional immediate release dosage form.
Keywords: Eprosartan mesylate HPMC K15M, HPMC E15, In-vitro buoyancy studies, In-vitro drug release.
Cite This Article:
Please cite this article in press Gudepu Chaithanya et al, Formulation And Evaluation Of Eprosartan Mesylate Floating Tablets, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
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