Volume : 10, Issue : 09, September – 2023
Title:
34.ENHANCED DISSOLUTION RATE OF EPALRESTAT SOLID DISPERSION – FORMULATION AND EVALUATION
Authors :
Aili Shilpa , Thadakapally Ramchander
Abstract :
Epalrestat was selected as a model drug, because it’s having poor aqueous solubility and low dissolution rate, while high permeability through the membranes (BCS class II drugs). So, the present work reveals the increasing the dissolution of Epalrestat without micronising it by solid dispersion technique. Solid dispersions were prepared using poloxamer-407, gelucire-50/13, PVPk-30, PEG 4000, PEG 6000 as carriers by physical mixing, solvent evaporation method techniques. The carrier concentration was taken in the ratios of 1:10, 1:20, and 1:30 with respect to the drug in the investigation. Effect of poloxamer-407, gelucire-50/13, PVPk-30, PEG 4000, PEG 6000 on solubility studies of Epalrestat was conducted in 0.1N HCl, distilled water, pH 6.8. the blend was subjected to precompression and post compression parameters. The In vitro drug release from the formulation follows the first order kinetics than zero order kinetics because of regression coefficient.
Keywords: Epalrestat, Solid dispersion, Physical mixing, Solvent evaporation method, carriers, In vitro drug release
Cite This Article:
Please cite this article in press Aili Shilpa et al, Enhanced Dissolution Rate Of Epalrestat Solid Dispersion – Formulation And Evaluation, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
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