Volume : 10, Issue : 09, September – 2023
Title:
38.FORMULATION AND EVALUATION OF BILAYER TABLETS OF METFORMIN AND LINAGLIPTIN
Authors :
K. Imran , Devara Raj kumar
Abstract :
The present study was to establish Bi-layer tablets of Metformin HCl and Linagliptin of which Metformin HCl as sustained release (SR) and Linagliptin as immediate release (IR) layer. Different amounts of crospovidone were utilized as disintegrating agents when making bilayered tablets, and HPMC K100, gattigum, and sodium alginate were used as sustained release polymers. The manufactured bilayered tablets underwent evaluations for homogeneity of drug content, hardness, weight fluctuation, thickness, friability, and in-vitro dissolution investigations. The maximum drug release for Formulations F6 and L4 for SR and IR, respectively, was seen to be up to 99.84% and 99.85% within 12 hours and 30 minutes, respectively. F6 was put through drug release kinetics tests that included zero order, first order, the Higuchi matrix, and Peppas model equations. Formulation F6 was prepared as the best formulation for (SR) based on several assessment factors, while L4 for (IR) was further subjected to a stability study. The formula had high stability, and the values were within the acceptable range. Thus, it may be concluded that stable bilayered tablet dosage forms for metformin’s prolonged release and linagliptin’s quick release are both possible.
Keywords: Anti-diabetic, Linagliptin, Metformin, Disintegrating agents, Immediate release layer, sustained release
Cite This Article:
Please cite this article in press K. Imran et al, Formulation And Evaluation Of Bilayer Tablets Of Metformin And Linagliptin, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
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