Volume : 10, Issue : 09, September – 2023
Title:
48.PHARMACOLOGICAL EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ALLIUM CEPA IN ANIMAL MODEL
Authors :
Teki Venkata Srujana*, Dr. Sanapala Arun Kumar
Abstract :
People in modern society suffer from different psychiatric disorders, particularly the depression. The exact cause of depression is unknown, but researchers suggest that depression is due to imbalancing of neurotransmitters like serotonin, norepinephrine, and dopamine in the brain. Factors that may contribute to depression include heredity, stress, chronic illnesses, certain personality traits and hormonal changes. However, several syntetic drugs are available in market, but all are associated with some limitations and there is an urgent need for alternative medications for these disorders.
Depression is a widely prevalent form of mental illnesses worldwide. It is commonly associated with sad mood, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, and low energy. Allium cepa has many medicinal properties, and are used in traditional medicine in the treatment of various medical conditions. This study was conducted to better understand the antidepressant activity of Allium cepa.
To evaluate the in vivo antidepressant activity of Methanolic extract of Allium cepa leave in Swiss albino mice. Methanolic extract of Allium cepa (EEAC) leaves was prepared by a continuous method using Soxhlet apparatus. The extract was subjected to phytochemical screening followed by acute oral toxicity studies in mice. EEAC in the doses of 100mg/Kg, 200mg/Kg and 400mg/Kg mg/kg body weight was administered to test groups Group 3, 4 and 5 respectively. Imipramine hydrochloride 15mg/kg body weight was administered to Standard group by oral route. Test group 3 received 100mg/kg (p.o). Control group received Normal saline 10ml/kg body weight. Antidepressant activity was identified by using modified Forced Swimming Test (FST) and Tail Suspension Test (TST). Period of immobility was observed in both the models which was indicative of anti-depressant activity. Standard statistical methods were used to evaluate the results. The results showed significant dose dependent antidepressant effect of EASL in Swiss albino mice for both the models in all the test groups (Test group I, II and III). EEAC possess significant antidepressant activity. However, further investigations are required to determine its active constituents and molecular level of target mechanism of the extract for further use in humans.
Keywords: Allium cepa, Antidepressant activity, forced swim test, Open Field Test.
Cite This Article:
Please cite this article in press Teki Venkata Srujana et al, Pharmacological Evaluation Of Antidepressant Activity Of Allium Cepa In Animal Model, Indo Am. J. P. Sci, 2023; 10 (09).
Number of Downloads : 10
References:
1. Stahl S.M., (2000). Psychopharmacology, 2nd Edition, New York, Cambridge University Press.
2. Van Oekelen D., Luyten W.H.M.L., Leysen J.E., (2003). 5-HT2A and 5-HT2C receptors and their atypical regulation properties. Life Sciences, 72, 2429-2449.
3. Cordi A.A., Berque-Bestel I., Persigand T., Lacoste J.M., Newman-Tancredi A., Audinot V., Millan M.J., (2001). Potential Antidepressants Displayed Combined 2- Adrenoceptor Antagonist and Monoamine Uptake Inhibitor Properties. Journal of Medicinal Chemistry, 44, 787-805.
4. Muller W.E .and Kasper S., (1997). Clinically used antidepressant drugs.Pharmacopsychiatry, 30(2), 102-107.
5. Besson A., Privat A.M., Eschalier A., Fialip J., (1999). Dopaminergic and opiodergic mediations of tricyclic antidepressants in the learned helplessness paradigm. Pharmacol Biochem Behav., 64(3), 541-548.
6. Hollister L.E. and Potter W.Z., (1998). Antidepressant agents. Basic and Clinical Pharmacology, 7th Edition, Edited by Bertram G Katzung, Appleton & Lange, Stamford, Connecticut, 483-495.
7. Rang H.P., Dele M.M., Ritter J.M., (1999). In Pharmacology (4th edition.) Churchill Livingstone, Edinburgh London, 550-565.
8. Li Yunfeng, Yang M., Zhao Y., Luo Z., (2000). Neuroprotective effect of Bajitian oligosaccharides on PC 12 cells damaged by corticosterone. Zhongguo Zhongyao Zazhi, 25, 551-554; Chem. Abstr. (2001) 134, 361243u.
9. Liao S., Kao Y.H., Hiipakka R.A., (2001). Green tea: biochemical and biological basis for health benefits. Vitam. Horm., 62, 1-94.
10. Steru L., Chermat R., Thierry B., Simon P., (1985). The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology. 85, 367–370.
11. Takeda H., Tsuji M., Matsumiya T., Kubo M., (2002). Identification of rosmarinic acid as a novel antidepressant substance in leaves of Perilla frutescens Britton var acut kudo. Nippon Shinkei Seishin Yakurigaku Zasshi, 22, 15-22; Chem. Abstr. (2002) 137, 332971.
12. Tariq M., Naveed A., Barkat Ali K., (2010). The morphology, characteristics, and medicinal properties of’ tea. J. Med. Plants Res., 4(19), 2028-2033.
13. Vadawa R.K. and Singh R.H., (1996). A clinical and experimental study on medhya effect of Aindri (Bacopa monieri L.). J. Res. Ayu Sidd., 17, 1-15; MAPA. (2000) 22, 3391.
14. Van Oekelen D., Luyten W.H.M.L., Leysen J.E., (2003). 5-HT2A and 5-HT2C receptors and their atypical regulation properties. Life Sciences, 72, 2429-2449.
15. Vijaya K., Ananthan S., Nalini R., (1995). Antibacterial effect of theaflavin, polyphenon Euphorbia hirta on Shigella spp., Journal of Ethnopharmacology, 49(2), 115–118.
16. Vural K., Ezer N., Erol K., Sahin F.P., (1996). Anxiolytic and antidepressant activities of some Ballota species. J. Fac. Pharm. Gazi. Univ., 13, 29-32; Chem. Abstr. (1996) 125, 292892 e.
17. Van Praag H.M., (1982). Neurotransmitters and CNS disease. The Lancet, 2, 1259- 1263.
18. Sheelendra Kumar Gupta and R.H. Singh; A clinical study on depressive illness and its Ayurvedic Management; J.R.A.S, 2020; 3-4: 82-93.
19. 3. Neena Bohra, Shruti Srivastava, and M.S. Bhatia; Depression in women in Indian context; Indian J Psychiatry, 2015; 57(2): S239–S245.
20. Acharya Vidhyadhar Shukla and Professor Ravidatta Tripathi, Chaukhamba Publication, Charak Samhita Nidan sthan adhya, 7: 4.
21. Pim Cuijpers corresponding author, Soledad Quero, Christopher Dowrick and Bruce Arroll: Psychological Treatment of Depression in Primary Care: Recent Developments Published online, 2019; 23
22. Zhao Z, Wang W, Guo H, Zhou D (2008). Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats. Behavioural Brain Research 194(1):108-113.
23. Galdino PM, Nascimento MVM, Sampaio BL, Ferreira RN, Paula JR, Costa EA (2009). Antidepressant-like effect of Lafoensia pacari A. St.-Hil. ethanolic extract and fractions in mice. Journal of Ethnopharmacology 124(3):581-585.