10.Issue 04 april 24 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 11, Issue : 04, April – 2024

Title:

RARE PRESENTATION OF SIGNET CELL ADENOCARCINOMA IN VICENARIAN: A CASE REPORT & LITERATURE REVIEW

Authors :

Amir Iqbal Ali , Sarosh Khan Jadoon, Amna Akbar , Misbah Abbas, Adnan Mehraj,Tanveer Hussain Mughal

Abstract :

Colorectal cancer (CRC) remains a significant contributor to cancer-related mortality, posing diagnostic and management challenges. Despite an overall decrease in CRC incidence, there has been an alarming rise in cases among young adults and adults. CRC, among various histopathological subtypes, signet ring cell carcinoma (SRCC) is comparatively infrequent but shows a higher prevalence in adults compared to older individuals. This subtype displays distinctive histological features, unique clinical characteristics, and unfortunately, a grim prognosis. Here, we present a primary case of signet ring cell adenocarcinoma located in the rectum, affecting a male of 29-year-old. The rare presentation and tumor’s location in these cases underscore the need for further investigation and research. We have also conduct a comprehensive literature review pertaining to metastatic SRCC, shedding light on significant findings in this area. This underscores the critical role of collaboration between clinicians and pathologists, emphasizing the importance of thorough histopathological, immunohistochemical, and molecular analyses. Such analyses serve as valuable tools for guiding investigations and facilitating informed management decisions.
Keywords: Signet ring cell carcinoma, colorectal cancer, grim prognosis, rectum

Cite This Article:

Please cite this article in press Sarosh Khan Jadoon et al, Rare Presentation Of Signet Cell Adenocarcinoma In Vicenarian: A Case Report & Literature Review ., Indo Am. J. P. Sci, 2024; 11 (4).

Number of Downloads : 10

References:

1. Vuik, F. E., Nieuwenburg, S. A., Nagtegaal, I. D., Kuipers, E. J., & Spaander, M. C. (2021). Clinicopathological characteristics of early onset colorectal cancer. Alimentary Pharmacology & Therapeutics, 54(11-12), 1463-1471. https://doi.org/10.1111/apt.16638
2. Collaborative, R. E. A. C. C. T., Zaborowski, A. M., Abdile, A., Adamina, M., Aigner, F., d’Allens, L., … & Otero, J. (2021). Characteristics of early-onset vs late-onset colorectal cancer: a review. JAMA Surgery, 156(9), 865-874. https://doi.org/10.1001/jamasurg.2021.2380
3. Wu, S. O. N. G., Wu, S. J., He, Y. L., Cai, S. R., Zhang, C. H., Zhang, X. H., & Zhan, W. H. (2009). Clinicopathologic features and survival of patients with colorectal mucinous, signet-ring cell or non-mucinous adenocarcinoma: experience at an institution in southern China. Chinese Medical Journal, 122(13), 1486-1491. https://doi.org/10.3760/cma.j.issn.0366-6999.2009.13.002
4. Clancy, E. (2023). ACS Report Shows Prostate Cancer on the Rise, Cervical Cancer on the Decline. Renal & Urology News, NA-NA.
5. Benesch, M. G., & Mathieson, A. (2020). Epidemiology of signet ring cell adenocarcinomas. Cancers, 12(6), 1544. https://doi.org/10.3390/cancers12061544
6. Song, I. H., Hong, S. M., Yu, E., Yoon, Y. S., Park, I. J., Lim, S. B., … & Kim, J. (2019). Signet ring cell component predicts aggressive behaviour in colorectal mucinous adenocarcinoma. Pathology, 51(4), 384-391. https://doi.org/10.1016/j.pathol.2019.03.001
7. Hyngstrom, J. R., Hu, C. Y., Xing, Y., You, Y. N., Feig, B. W., Skibber, J. M., … & Chang, G. J. (2012). Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base. Annals of Surgical Oncology, 19, 2814-2821. doi: https://doi.org/10.1245/s10434-012-2321-7
8. Chen, J. S., Hsieh, P. S., Hung, S. Y., Tang, R., Tsai, W. S., Changchien, C. R., … & Yeh, C. Y. (2004). Clinical significance of signet ring cell rectal carcinoma. International Journal of Colorectal Disease, 19, 102-107. https://doi.org/10.1007/s00384-003-0515-y
9. Lee, W. S., Chun, H. K., Lee, W. Y., Yun, S. H., Cho, Y. B., Yun, H. R., … & Song, S. Y. (2007). Treatment outcomes in patients with signet ring cell carcinoma of the colorectum. The American Journal of Surgery, 194(3), 294-298 https://doi.org/10.1016/j.amjsurg.2006.12.041
10. Laufman, H., & Saphir, O. (1951). Primary linitis plastica type of carcinoma of the colon. AMA Archives of Surgery, 62(1), 79-91. https://doi.org/10.1001/archsurg.1951.01250030082009
11. Giacchero, A., Aste, H., Baracchini, P., Conio, M., Fulcheri, E., Lapertosa, G., & Tanzi, R. (1985). Primary signet‐ring carcinoma of the large bowel report of nine cases. Cancer, 56(11), 2723-2726.
12. Almagro, U. A. (1983). Primary signet‐ring carcinoma of the colon. Cancer, 52(8), 1453-1457.
13. Zhou, J. L., Zhao, X. Y., Lin, G. L., Qiu, H. Z., Xiao, Y., Wu, B., … & Zhong, G. X. (2020). Clinicopathological characteristics, diagnosis, and treatment of 29 cases of signet ring cell carcinoma of the rectum and sigmoid colon. Zhonghua Zhong liu za zhi [Chinese Journal of Oncology], 42(10), 897-902. https://doi.org/10.3760/cma.j.cn112152-20200228-00142
14. Fahl, J. C., Dockerty, M. B., & Judd, E. S. (1960). Scirrhous carcinoma of the colon and rectum. Surgery, Gynecology & Obstetrics, 111, 759-766.
15. Amorn, Y., & Knight Jr, W. A. (1978). Primary linitis plastica of the colon. Report of two cases and review of the literature. Cancer, 41(6), 2420-2425.
16. Kang, H., O’Connell, J. B., Maggard, M. A., Sack, J., & Ko, C. Y. (2005). A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Diseases of the Colon & Rectum, 48(6), 1161-1168. https://doi.org/10.1007/s10350-004-0932-1
17. An, Y., Zhou, J., Lin, G., Wu, H., Cong, L., Li, Y., … & Shi, W. (2021). Clinicopathological and molecular characteristics of colorectal signet ring cell carcinoma: a review. Pathology and Oncology Research, 27, 1609859. https://doi.org/10.3389/pore.2021.1609859
18. Yang, L. L., Wang, M., & He, P. (2020). Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study. Scientific Reports, 10(1), 10460. https://doi.org/10.1038/s41598-020-67388-6
19. Zhu, L., Ling, C. R., Xu, T., Zhang, J., Zhang, Y., Liu, Y., … & Wang, M. (2021). Clinicopathological features and survival of signet-ring cell carcinoma and mucinous adenocarcinoma of right colon, left colon, and rectum. Pathology and Oncology Research, 27, 1609800. https://doi.org/10.3389/pore.2021.1609800
20. Fu, K. I., Sano, Y., Kato, S., Saito, H., Ochiai, A., Fujimori, T., … & Yoshida, S. (2006). Primary signet-ring cell carcinoma of the colon at early stage: a case report and a review of the literature. World Journal Of Gastroenterology: WJG, 12(21), 3446. https://doi.org/10.3748/wjg.v12.i21.3446
21. Zhu, L., Ling, C. R., Xu, T., Zhang, J., Zhang, Y., Liu, Y., … & Wang, M. (2021). Clinicopathological features and survival of signet-ring cell carcinoma and mucinous adenocarcinoma of right colon, left colon, and rectum. Pathology and Oncology Research, 27, 1609800. https://doi.org/10.3389/pore.2021.1609800
22. Shirouzu, K., Isomoto, H., Morodomi, T., Ogata, Y., Akagi, Y., & Kakegawa, T. (1994). Primary linitis plastica carcinoma of the colon and rectum. Cancer, 74(7), 1863-1868.
23. Yepuri, N., Naous, R., Richards, C., Dhir, M., & Jain, A. (2018). Poorly differentiated signet ring cell carcinoma of pancreas masquerading as chronic pancreatitis. Journal of Surgical Case Reports, 2018(8), rjy218. https://doi.org/10.1093/jscr/rjy218
24. Dietvorst, M. H., Schoenmakers, N., & ten Tije, A. J. (2013). A man with colorectal signet ring cell carcinoma: Which therapy is required?. Nederlands Tijdschrift Voor Geneeskunde, 157(20), A5507-A5507.
25. Zhou, J. L., Zhao, X. Y., Lin, G. L., Qiu, H. Z., Xiao, Y., Wu, B., … & Zhong, G. X. (2020). Clinicopathological characteristics, diagnosis, and treatment of 29 cases of signet ring cell carcinoma of the rectum and sigmoid colon. Zhonghua Zhong liu za zhi [Chinese Journal of Oncology], 42(10), 897-902. https://doi.org/10.3760/cma.j.cn112152-20200228-00142
26. Chu, P. G., & Weiss, L. M. (2004). Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. American Journal of Clinical Pathology, 121(6), 884-892. https://doi.org/10.1309/A09E-RYMF-R64N-ERDW
27. Posey, J. T., Neulander, E. Z., Soloway, M. S., & Civantos, F. (2000). Signet ring cell carcinoma of a pulled-through sigmoid colon mimicking a primary invasive bladder tumor: case report and review of the literature. Urology, 55(6), 949. https://doi.org/10.1016/s0090-4295(00)00477-5
28. Khan, M., Korphaisarn, K., Saif, A., Foo, W. C., & Kopetz, S. (2017). Early-onset signet-ring cell adenocarcinoma of the colon: a case report and review of the literature. Case Reports in Oncological Medicine, 2017. https://doi.org/10.1155/2017/2832180
29. Kang, S. H., Chung, W. S., Hyun, C. L., Moon, H. S., Lee, E. S., Kim, S. H., … & Jeong, H. Y. (2012). A rare case of a signet ring cell carcinoma of the colon mimicking a juvenile polyp. Gut and Liver, 6(1), 129. https://doi.org/10.5009/gnl.2012.6.1.129.