Volume : 11, Issue : 04, April – 2024
Title:
A REVIEW ARTICLE ON GASRORETENTIVE DRUG DELIVERY SYSTEM
Authors :
Dr.S.K Rubina* S.Sameer
Abstract :
The development of formulations based on prolongation of gastric residence has been gaining significant attention of the researchers. Stomach is a major organ of the digestive system and plays a significant role in drug absorption too. The gastrointestinal (GI) tract is highly heterogeneous in nature with wide variation in the pH, size of the segment, structure of the membrane, vascularity and smoothness of inner mucosa, etc. The residence time of the ingested matter, including drugs, is also not uniform throughout. The normal gastric residence time, i.e., around two hours, may not be sufficient for the complete absorption of drugs which are absorbed predominantly from stomach. Moreover, for the drugs acting locally in stomach for conditions such as hyperacidity, peptic ulcer or gastric infection, prolonging the residence time may prove to be advantageous. Medicinal substances, which cause irritation in the intestine or are degraded in the intestinal environment, are preferentially formulated as gastroretentive (GR) dosage forms too. Various strategies such as floating delivery systems, mucoadhesive formulations, high density systems and swelling dosage forms are invariably used to achieve enhancement in gastric residence time. The current chapter endeavors to discuss the stellar merits and limitations of each approach, their evaluation and characterization aspects including gastroretention and bioavailability studies. Each of such systems has also been duly illustrated citing laboratory instances, and/or apt literature reports.
Cite This Article:
Please cite this article in press S.Sameer et al., A Review Article On Gasroretentive Drug Delivery System., Indo Am. J. P. Sci, 2024; 11 (04).
Number of Downloads : 10
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