Volume : 11, Issue : 01, January – 2024
Title:
THE ASSOCIATION BETWEEN TYPE 2 DIABETES AND DEMENTIA IN ELDERLY PATIENTS: SYSTEMATIC REVIEW
Authors :
Haifa Eissa Almahasneh, Zahra Ebrahim Alramel , Raheeq Jafeer Alolaian, Razan Mohammed Al-Issa, Fatimah Mustafa Alsalim , Zahra Ahmed Alyaseen , Anoar Jafeer Alolaian, Zinab Shaker Alsabaa
Abstract :
Objectives: To investigate the association between diabetes and dementia in elderly patients, with a focus on understanding the potential risk factors, pathophysiological mechanisms, and clinical implications of this relationship.
Methods: A thorough search was conducted for pertinent literature using PubMed, SCOPUS, Web of Science, Science Direct, and Wiley Library. Rayyan QRCI was used throughout this extensive procedure.
Results: Our results included eleven studies with a total of 5,758,607 patients. The follow-up duration ranged from 1 year to 12 years. It is common for older diabetic individuals to have cognitive impairment that is not diagnosed. There is a substantial correlation between glycated albumin, glycated albumin/HbA1c, IL-6, superoxide dismutase, poor diabetes self-management, decreased BMI, weight loss and the cognitive performance of senior T2D patients. One study found that metformin has a protective effect on dementia risk in T2D patients while the other reported that it has no effect. Old women with T2D showed higher rates of cognitive impairment as well as lower levels of executive and global cognitive function. One study reported that lower cognitive functioning is independently correlated with larger burdens of amyloid and small vessel disease.
Conclusion: There is strong evidence that individuals with diabetes have a higher risk of dementia, however comprehensive epidemiological data about risk factors are scarce. The potential link between diabetes and dementia is attracting more attention in the scientific community since it is a highly relevant topic from both a public health and scientific standpoint. Investigating this connection might make some new pathways leading to neurodegeneration clearer.
Keywords: dementia, diabetes, T2DM, cognitive function, geriatrics, elderly.
Cite This Article:
Please cite this article in press Haifa Eissa Almahasneh et al., The Association Between Type 2 Diabetes And Dementia In Elderly Patients: Systematic Review, Indo Am. J. P. Sci, 2024; 11 (01).
Number of Downloads : 10
References:
1. Cholerton B, Baker LD, Montine TJ, Craft S. Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach. Diabetes Spectr. 2016;29(4):210-219. doi:10.2337/ds16-0041
2. Sherzai, D., Sherzai, A., Lui, K., Pan, D., Chiou, D., Bazargan, M., & Shaheen, M. (2016). The Association Between Diabetes and Dementia Among Elderly Individuals: A Nationwide Inpatient Sample Analysis. Journal of geriatric psychiatry and neurology, 29(3), 120–125. https://doi.org/10.1177/0891988715627016
3. Biessels GJ, Despa F. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications. Nat Rev Endocrinol. 2018;14(10):591-604. doi:10.1038/s41574-018-0048-7
4. Ravona-Springer R, Schnaider-Beeri M. The association of diabetes and dementia and possible implications for nondiabetic populations. Expert Rev Neurother. 2011;11(11):1609-1617. doi:10.1586/ern.11.152
5. Momtaz YA, Hamid TA, Bagat MF, Hazrati M. The Association Between Diabetes and Cognitive Function in Later Life. Curr Aging Sci. 2019;12(1):62-66. doi:10.2174/1874609812666190614104328
6. Hassing LB, Grant MD, Hofer SM, et al.. Type 2 diabetes mellitus contributes to cognitive decline in old age: a longitudinal population-based study. J Int Neuropsychol Soc 2004;10:599–607
7. Strachan MWR. D. Lawrence Lecture 2010: The brain as a target organ in type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med 2011;28:141–147
8. Yaffe K, Blackwell T, Kanaya AM, Davidowitz N, Barrett-Connor E, Krueger K. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004;63:658–663
9. Shaik MA, Chan QL, Xu J, et al.. Risk factors of cognitive impairment and brief cognitive tests to predict cognitive performance determined by a formal neuropsychological evaluation of primary health care patients. J Am Med Dir Assoc 2016;17:343
10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International journal of surgery. 2021 Apr 1;88:105906.
11. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Systematic reviews. 2016 Dec;5:1-0.
12. Munn Z, Aromataris E, Tufanaru C, Stern C, Porritt K, Farrow J, Lockwood C, Stephenson M, Moola S, Lizarondo L, McArthur A. The development of software to support multiple systematic review types: the Joanna Briggs Institute System for the Unified Management, Assessment and Review of Information (JBI SUMARI). JBI evidence implementation. 2019 Mar 1;17(1):36-43.
13. Lesman-Segev OH, Golan Shekhtman S, Springer RR, Livny A, Lin HM, Yuxia O, Zadok M, Ganmore I, Heymann A, Hoffmann C, Domachevsky L. Amyloid deposition and small vessel disease are associated with cognitive function in older adults with type 2 diabetes. Scientific Reports. 2024 Feb 1;14(1):2741.
14. Merzon E, Shpigelman M, Vinker S, Cohen AG, Green I, Israel A, Cukierman-Yaffe T, Eldor R. Clinical characteristics and healthcare utilisation associated with undiagnosed cognitive impairment in elderly patients with diabetes in a primary care setting: a population-based cohort study. BMJ open. 2024;14(1).
15. Si SC, Yang W, Luo HY, Ma YX, Zhao H, Liu J. Cognitive decline in elderly patients with type 2 diabetes is associated with glycated albumin, ratio of Glycated Albumin to glycated hemoglobin, and concentrations of inflammatory and oxidative stress markers. Heliyon. 2023 Dec 1;9(12).
16. Kim MJ, Bronas UG, Quinn L, Sharp LK, Park C, Gruss V, Fritschi C. Cognitive function and self-management behaviors in older adults with type 2 diabetes. Nursing Research. 2022 Apr 13:10-97.
17. Zheng B, Su B, Ahmadi‐Abhari S, Kapogiannis D, Tzoulaki I, Riboli E, Middleton L. Dementia risk in patients with type 2 diabetes: comparing metformin with no pharmacological treatment. Alzheimer’s & Dementia. 2023 Dec;19(12):5681-9.
18. Chen HF, Jiang JY, Chen MH, Lin R, Jerence SW, Chang CH, Chou CC. Gender differences in cognitive function and its associated factors among older adults with type 2 diabetes. Geriatric Nursing. 2023 Jul 1;52:165-71.
19. Lopez-de-Andres A, Jimenez-Garcia R, Zamorano-Leon JJ, Omaña-Palanco R, Carabantes-Alarcon D, Hernández-Barrera V, De Miguel-Diez J, Cuadrado-Corrales N. Prevalence of Dementia among Patients Hospitalized with Type 2 Diabetes Mellitus in Spain, 2011–2020: Sex-Related Disparities and Impact of the COVID-19 Pandemic. International Journal of Environmental Research and Public Health. 2023 Mar 10;20(6):4923.
20. Chen BJ, Sluiman AJ, Khalid W, Strachan MW, Price JF. Risk of dementia associated with body mass index, changes in body weight and waist circumference in older people with type 2 diabetes: The Edinburgh Type 2 Diabetes Study. Diabetic Medicine. 2023 Feb 8:e15063.
21. Xue Y, Xie X. The Association between Metformin Use and Risk of Developing Severe Dementia among AD Patients with Type 2 Diabetes. Biomedicines. 2023 Oct 30;11(11):2935.
22. Cho S, Kim CO, Cha BS, Kim E, Nam CM, Kim MG, Park MS. The effects of long-term cumulative HbA1c exposure on the development and onset time of dementia in the patients with type 2 diabetes mellitus: Hospital based retrospective study (2005–2021). Diabetes Research and Clinical Practice. 2023 Jul 1;201:110721.
23. Chau YL, Yoo JW, Zhou J, LiutaoGuo C, Wong WT, Chang C, Liu T, Jeevaratnam K, Zhang Q, Tse G, Lee S. Risk factors of dementia in type 2 diabetes mellitus: The Hong Kong diabetes study. Aging and Health Research. 2023 Sep 1;3(3):100155.
24. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P. Risk of dementia in diabetes mellitus: a systematic review. The Lancet Neurology. 2006 Jan 1;5(1):64-74.
25. Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 2000; 23: 542–49.
26. Neuropathology Group. Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet 2001; 357: 169–75.
27. Geijselaers SL, Sep SJ, Stehouwer CD, Biessels GJ. Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review. The Lancet Diabetes & Endocrinology. 2015 Jan 1;3(1):75-89.
28. Stewart R, Liolitsa D. Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 1999; 16: 93–112
29. Biessels GJ, Kamal A, Ramakers GM, et al. Place learning and hippocampal synaptic plasticity in streptozotocin-induced diabetic rats. Diabetes 1996; 45: 1259–66.
30. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001; 414: 813–20.
31. Biessels GJ, Van der Heide LP, Kamal A, Bleys RL, Gispen WH. Ageing and diabetes: implications for brain function. Eur J Pharmacol 2002; 441: 1–14.
32. de la Torre JC. Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer’s pathogenesis. Neurobiol Aging 2000; 21: 331–42.
33. Araki Y, Nomura M, Tanaka H, Yamamoto H, Yamamoto T, Tsukaguchi I. MRI of the brain in diabetes mellitus. Neuroradiology 1994; 36: 101–03.
34. Engler-Chiurazzi EB, Singh M, Simpkins JW. From the 90׳ s to now: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain research. 2016 Feb 15;1633:96-100.
35. Livingston G, Sommerlad A, Orgeta V, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113): 2673–2734.
36. Livingston G, Huntley J, Sommerlad A, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248): 413–446.