Volume : 11, Issue : 06, June – 2024
Title:
REVIEW ON NANOSUSPENSION TECHNOLOGY
Authors :
Puja Aher*, Rajesh Mokate
Abstract :
Solubility is a essential factor for developing drug delivery system for poorly water soluble drugs. Most of the recently discovered drugs are insoluble in water and hence poorly absorb with reduced bioavailability that leads to more production efforts.Nanosuspension is a simple and more beneficial than other approaches. Technique like high pressure homogenization, wet milling, bottom up technology and top down technology have been applicable for manufacturing of Nano suspension. They are delivered by various routes such as parenteral, oral, ocular and pulmonary route.
Keywords- Nano suspension, Solubility, Surfactants, Poor soluble drug, Manufacturing, Application, Bioavailability.
Cite This Article:
Please cite this article in press Puja Aher et al Review On Nanosuspension Technology .,Indo Am. J. P. Sci, 2024; 11 (6).
Number of Downloads : 10
References:
[1] Xiaohui P, Jin S, Mo L, Zhonggui H, Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs, Current Nanoscience 2009; 5: 417-427
[2] Wagh KS, Patil SK, Akarte AK, Baviskar DT, Nano suspension – A New Approach of Bioavailability Enhancement, International Journal of Pharmaceutical Sciences Review and Research, 2011; 8: 61-65.
[3]Patil SA, Rane BR, Bakliwal SR, Pawar SP, Nano suspension: At A Glance, International Journal of Pharmaceutical Science, 2011; 3(1): 947-960.
[4] Bansal.S, Bansal M, Kumria R, Nanocrystals: Current Strategies and Trends, International Journal of Research in Pharmaceutical and Biomedical Sciences, 2012; 3 (1): 406- 419
[5] Pandey S, Nano suspension: Formulation, Charcterization and Evaluation, International Journal of Pharma and Bio Sciences, 2010; 1(2): 1-10.
[6] Date, AA; Kulkarni , RM and Patravale , VB(2004), “Nanosuspensions: A promising drug delivery”,Journal of Pharmacy and Pharmacology, 56:827-840.
[7]Barret ER.Nanosuspension in drug delivery Nat Rev.2004;3:785-96.
[8]Vermaa S,Lan Y,Gokhale R,Burgessa DJ.Quality by design approach to understand process of nanosuspension preparation.Int J Pharm.2009;377:185-98.
[9]VB Patravale,AA Date and RM Kulkarni.Nanosuspension:a promising drug delivery strategy.J.Pharm.Phamacol.2004;56,827-40.
[10]Mitrovic JR,Divovic B,Knutson DE,Dokovic JB,Vulic PJ,Randjelovic DV,et al.Nanocrystal dispersion of DK-I-56-1,a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors:Formulation approach towards improve in in vivo performance.European Journal of Pharmaceutical Sciences.2020;152(2020):1-12
[11]Tehrani AA,Omranpoor MM,Vatanara A,Seyedabadi M, Ramezani V. Formation of nanosuspentions in bottom-up approach : theories and optimization.DARU Journal of Pharmaceutical Sciences.2019;27(2019):451-73.
[12]Liversidage GG,Cundy KC. Particle size reduction for improvement of oral bioavailability of hydrophiobic drugs: Absolute oral bioavailability of nanocrystalline danazol in beagle dogs.Int
J Pharm. 1995; 125:91-7.
[13]Venkatesh T, Nanosuspensions: Ideal Approach for the Drug Delivery of Poorly Water Soluble Drugs, Der Pharmacia Lettre, 2011; 3(2): 203-213. [16]1
[14]Prasanta D,Nanotechnology for the delivery of poorly solublr drugs,The Global Journal of Pharmaceutical Research,1(3),2012,225-250.
[15] Oktay AN,IIbasmis-Tamer S,Karakucuk A,Celebi N.Screening of Stabilizing agent to optimize flurbiprofen nanosuspensions using experimental design.Journal of Drug Delivery Science Technology.2020;57(2020):1-12.
[16] Mathew A,Jacob S,Shyma M.Nanosuspension Loaded Oral Films:A Breakthrough Approach.Journal of Pharmaceutical Science and Research. 2020;12(8)1012-7.
[17] Nayak BS, Mohanty B, Roy H,Patnaik A.Nanosuspension:Bioavailability enhancing novel approach.International journal of pharmacy and biological sciences.2018;8(2):540-54.
[18] Khandbahale SV. A Review-Nanosuspension Technology in Drug Delivery System .Asian Journal of Pharmaceutical Research.2019;9(2):130-8.
[19] Li G, Lu Y, Fan Y, Ning Q, Li W.Enhance oral bioavailability of magnolol via mixed micelles and nano suspensions based on soluplus ®- Poloxamer 188.Drug Delivery.2020;27[1]:1010-7.
[20]Xing Y, Lu P,Xue Z, Liang C,Zhang B, Kebebe D, et al.Nano-Strategies for Improving the Bioavalibility of Inhaled Pharmaceutical Formulation.Mini reviews in medicinal chemistry.2020;20(13):1258-71.
[21]Heidi MM, Yun-Seok R, Xiao W.Nanomedicine in pulmonary delivery. Int J Nanomed.2009;4:299-399
[22]Ahire E Thakkar S Darshanwad M,Misra M. Prenteral nanosuspensions : a brief review from solubility enhancement more novel and specific application. Acta Pharamacetica Sinica B.2018;8(5):733-55.
[23]Liversidge EM ,Liversidge GG,Cooper ER, Nanosizing : A formulation approach for poorly -water-soluble compounds.Eur J Pharm Sci.2003;18:113-20.
[24] Kayser O,Lemke A, Hernandz-Trejo N. The impact of Nanobiotechnology on the development of new drug delivery system. Curr Pharm Biotech.2005;6:3-5.
[25]Bhumaekar P,Mishra R, Dubey B. Development chitosan grafted nanosuspension for ocular delivery of ciprfloxacin. International journal of pharmacy practice and pharmaceutical sciences2019;1[2]79-85.
[26] Liang YC, Binner JG. Effect of triblock copolymer non-ionic surfactant on the rheology of 3 mol % yttria stabilised zirconia nanosuspensions . Ceram Int.2008; 34:293-7.
[27] Grau MJ, Kayser O,Muller RH. Nanosuspensions of poorly soluble drugs reproducibility of small-scale production.Int J Pharm.2000;196:155-7.
[28]Hintz RJ, Johnson KC. The effect of paetical size distribution on dissolution rate and oral absorption.Int J Pharm .1989;51:9-17.