Volume : 11, Issue : 03, March – 2024
Title:
A REVIEW OF IN SILICO TOXICOLOGICAL STUDIES
Authors :
G. Neha*, Mrs. Padmajadevi. M. S., Mr. Dileep. C. Babu, Ms. Renjitha R.S, Ms. Hashima
Abstract :
In the realm of toxicology, where safety is paramount, in silico studies are emerging as a powerful and innovative approach to assessing the potential hazards of chemicals. Unlike traditional methods that rely on animal testing, in silico toxicology leverages the power of computational modeling to predict and analyse a chemical’s toxicity profile. This translates to a multitude of advantages. In silico methods offer a significant leap in efficiency. By utilizing computer models trained on vast datasets of existing chemical information, researchers can rapidly assess a new chemical’s potential to interact with biological systems. This eliminates the need for lengthy and resource-intensive animal testing in the initial stages of safety evaluation. In silico toxicology promotes a more ethical approach. By reducing or potentially eliminating the use of animals in safety testing, these computational methods align with the growing movement towards humane research practices. This is particularly important when dealing with chemicals for which obtaining sufficient quantities for animal testing might be impractical. Furthermore, in silico studies provide valuable insights for guiding further toxicological investigations. The predictions generated by these models help researchers prioritize which chemicals warrant more in-depth testing using cell-based assays or even animal models. This targeted approach optimizes resource allocation and streamlines the safety assessment process. However, it’s crucial to recognize that in silico toxicology is still a developing field. The accuracy of predictions hinges on the quality and comprehensiveness of the underlying data used to train the models. Additionally, these models often focus on specific toxicity endpoints, such as skin irritation or organ damage. Therefore, in silico methods are best employed as a complementary tool alongside traditional testing methods, providing a more comprehensive picture of a chemical’s safety profile. In conclusion, in silico toxicology represents a significant advancement in the field of safety assessment. By offering a faster, more ethical, and data-driven approach to predicting chemical toxicity, these computational methods hold immense promise for streamlining safety testing while promoting the development of safe and sustainable chemicals.
KEYWORDS: In silico toxicology, Toxicity, Computational modeling, Molecular Docking
Cite This Article:
Please cite this article in press G. Neha et al., A Review Of In Silico Toxicological Studies., Indo Am. J. P. Sci, 2024; 11 (03).
Number of Downloads : 10
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